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Updated: Mar 25, 2026

A Tuberculosis Molecular Bacterial Load Assay TB-MBLA
Published on: April 30, 2020
A 1-Year-Old with Mycobacterium tuberculosis Endocarditis with Mass Spectrometry Analysis of Cardiac Vegetation
Laura A Sass1, Keegan J Ziemba2, Elizabeth A Heiser2
1The Departments of Pediatrics The Children's Hospital of The King's Daughters, Norfolk, Virginia Children's Specialty Group, Norfolk, Virginia.
Abstract:
In this study, we report the first case of Mycobacterium tuberculosis endocarditis in an immunocompetent child born in the United States. Mass spectrometry of the vegetation identified coagulation, humoral immune proteins, neutrophil granule proteins, and histones. Few neutrophils on histopathology suggest that neutrophil extracellular traps may contribute to tuberculous endocardiac mass formation.
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