Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Systems Approach to Endophyte-Mediated Plant Holobiont and Microbiome Dynamics.

Plants (Basel, Switzerland)·2026
Same author

Accelerated TMS with the H1-coil for depression: A multisite, randomized non-inferiority trial.

Brain stimulation·2026
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026
Same author

Clinical practice guidelines for the management of bipolar disorder: 2025 update.

Indian journal of psychiatry·2026
Same author

Patient-reported outcomes following accelerated vs. standard TMS with the H1 coil for major depression: A multisite randomized trial.

Brain stimulation·2026
Same author

H7 Coil Deep Repetitive Transcranial Magnetic Stimulation in Patients With Obsessive-Compulsive Disorder: Do Factors Like Age, Sex, and Medication Affect Clinical Outcomes?

Cureus·2025
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Mar 25, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

3.3K

A Randomized Clinical Trial Evaluating rh-FGF-2/β-TCP in Periodontal Defects.

D L Cochran1, T-J Oh2, M P Mills3

  • 1Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Cochran@uthscsa.edu.

Journal of Dental Research
|February 25, 2016
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor 2 (FGF-2) combined with a β-tricalcium phosphate (β-TCP) scaffold significantly enhanced periodontal regeneration in vertical infrabony defects. Higher FGF-2 doses (0.3% and 0.4%) showed improved bone fill and clinical attachment compared to controls.

Keywords:
alveolar bone lossbiological factorsbone substitutesperiodontal diseaserandomized controlled trialregeneration

More Related Videos

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.4K

Related Experiment Videos

Last Updated: Mar 25, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

3.3K
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.9K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.4K

Area of Science:

  • Periodontal regeneration
  • Biomaterials in dentistry
  • Tissue engineering

Background:

  • Periodontal regeneration aims to restore lost tissues.
  • Biological mediators are explored to enhance regenerative outcomes.
  • Vertical infrabony defects pose significant regenerative challenges.

Purpose of the Study:

  • To evaluate the safety and effectiveness of three doses of fibroblast growth factor 2 (FGF-2) combined with a β-tricalcium phosphate (β-TCP) scaffold.
  • To assess the dose-response relationship of rh-FGF-2 in treating vertical infrabony periodontal defects.
  • To compare rh-FGF-2/β-TCP treatments against a β-TCP alone control.

Main Methods:

  • Prospective, randomized, double-blind, controlled clinical study involving 88 adult patients.
  • rh-FGF-2 (0.1%, 0.3%, 0.4%) combined with β-TCP scaffold implanted in vertical infrabony defects.
  • Assessment of clinical attachment gain, bone fill, and safety parameters over 6 months.

Main Results:

  • A dose-response pattern was observed, with 0.3% and 0.4% rh-FGF-2/β-TCP showing significant improvements.
  • Success rates were 71% in higher concentration groups versus 45% in control and 0.1% groups.
  • Mean bone fill was 75% and 71% in higher dose groups, compared to 63% and 61% in lower dose/control groups.
  • No specific antibodies to rh-FGF-2 or serious adverse events were reported.

Conclusions:

  • The addition of rh-FGF-2 to β-TCP scaffolds enhances periodontal regeneration in vertical infrabony defects.
  • Optimal regenerative outcomes were achieved with 0.3% and 0.4% rh-FGF-2 concentrations.
  • rh-FGF-2/β-TCP combination therapy is a safe and effective treatment option for infrabony periodontal defects.