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Related Experiment Video

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Maturation Along White Matter Tracts in Human Brain Using a Diffusion Tensor Surface Model Tract-Specific Analysis.

Zhang Chen1, Hui Zhang2, Paul A Yushkevich3

  • 1Department of Biomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta Edmonton, AB, Canada.

Frontiers in Neuroanatomy
|February 25, 2016
PubMed
Summary
This summary is machine-generated.

Brain white matter (WM) development shows distinct spatial patterns along major tracts, varying by sex and tract. Diffusion parameters like fractional anisotropy (FA) and mean diffusivity (MD) mature at different rates and ages across the brain.

Keywords:
diffusion tensor imagingfractional anisotropymean diffusivityneurodevelopmenttractography

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Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Human Brain Anatomy

Background:

  • Previous diffusion tensor imaging (DTI) studies analyzed white matter (WM) tract development using averaged diffusion parameters.
  • These studies assumed uniform developmental changes across entire tracts, potentially overlooking regional variations.
  • Tract-specific analysis is needed to spatially characterize age-related WM maturation.

Purpose of the Study:

  • To spatially characterize age-related changes in fractional anisotropy (FA) and mean diffusivity (MD) along specific white matter (WM) tracts.
  • To investigate regional differences in developmental trajectories of FA and MD within major WM tracts.
  • To examine sex-specific patterns in WM maturation.

Main Methods:

  • A surface model-based, tract-specific analysis was applied to diffusion tensor imaging (DTI) data.
  • 178 healthy subjects (ages 6–30 years) were analyzed cross-sectionally.
  • FA and MD changes were mapped along seven major WM tracts, including the corpus callosum (CC) and bilateral tracts.

Main Results:

  • Unique regional patterns of FA increase and MD decrease were observed along each tract, with varying maturation timelines.
  • Faster FA changes occurred in the genu of the CC and the frontal-parietal SLF; earlier FA changes were noted in posterior association tracts and CST.
  • A posterior-to-anterior maturation pattern for MD was observed in females. Males reached FA maxima/MD minima later than females, particularly in CST and frontal-parietal SLF.

Conclusions:

  • Human brain white matter (WM) development exhibits spatially heterogeneous trajectories along major tracts.
  • Maturation patterns of FA and MD are tract-specific and influenced by sex.
  • Tract-specific analysis reveals nuanced developmental processes in WM beyond global averages.