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Updated: Mar 25, 2026

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
Published on: May 10, 2022
Ubiquitin proteasome system research in gastrointestinal cancer
Jia-Ling Zhong1, Chang-Zhi Huang1
1Jia-Ling Zhong, Clinical Laboratory Department, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
Abstract:
The ubiquitin proteasome system (UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal malignancies, including esophageal, gastric and colorectal cancers. Here, we summarize the current literature detailing the involvement of the UPS in gastrointestinal cancer, highlighting its role in tumor occurrence and development, providing information for therapeutic targets research and anti-gastrointestinal tumor drug design.
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