Data on coronary artery calcium score performance and cardiovascular risk reclassification across gender and...

Area of Science:

• Cardiology
• Preventive Medicine
• Medical Imaging

Background:

• Current guidelines recommend the Atherosclerotic Cardiovascular Disease (ASCVD) score for predicting future cardiovascular disease (CVD) events.
• Limited data exist on the combined predictive utility of the ASCVD score and coronary artery calcium scoring (CACS) across diverse demographic groups.

Purpose of the Study:

• To evaluate the predictive accuracy of the ASCVD score alone and in combination with CACS for CVD events.
• To assess the incremental value of CACS across different genders and ethnicities.

Main Methods:

• Post-hoc analysis of 6742 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
• Utilized pooled cohort equations based on American College of Cardiology/American Heart Association guidelines.
• Compared the analytical properties of models with and without CACS for CVD prediction.

Main Results:

• The ASCVD score demonstrated predictive utility for CVD events.
• The addition of CACS provided incremental predictive value.
• Performance of the ASCVD score and CACS varied across gender and ethnic groups.

Conclusions:

• The ASCVD score is a valuable tool for assessing CVD risk.
• Coronary artery calcium scoring (CACS) enhances CVD risk prediction when combined with the ASCVD score.
• Further research is needed to refine risk prediction models for diverse populations.