Related Experiment Video
Updated: Mar 25, 2026
Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung
Published on: January 22, 2021
Prior antibacterial drug exposure in dogs with meticillin-resistant Staphylococcus pseudintermedius (MRSP) pyoderma
Nao Hensel1, Sonja Zabel2, Patrick Hensel1
1Tierdermatologie Basel, Emil Frey-Strasse 127, CH-4142, Münchenstein, Switzerland.
Background:
The emergence of meticillin-resistant Staphylococcus pseudintermedius (MRSP) has become a significant animal health problem. Recent studies have indicated that previous antibacterial drug exposure is a factor in acquisition of meticillin-resistant strains of staphylococci.
Hypothesis/Objectives:
The purpose of this study was to identify factors associated with prior antimicrobial drug use and MRSP pyoderma in dogs presented to a veterinary teaching hospital.
Animals:
Dogs diagnosed with pyoderma associated with MRSP (n = 53) or meticillin-sensitive S. pseudintermedius (MSSP; n = 45).
Methods:
The medical records of dogs diagnosed with pyoderma associated with isolation of S. pseudintermedius between January 2006 and November 2012 were reviewed. All cases with a complete twelve month to 3 yr drug history prior to the diagnosis were included.
Results:
Fifty two of 53 (98%) MRSP cases and 42 of 45 (93%) MSSP cases had received at least one course of antibacterial drug prior to diagnosis. The total number of antibacterial drug prescriptions provided to pet owners and the variety of antibacterial drug classes represented were higher for cases with MRSP than for cases with MSSP (P < 0.0001 and P = 0.009, respectively). More cases with MRSP (98%) received beta-lactam drugs than those with MSSP (82%; P = 0.007) and the proportion of MRSP cases that had received concurrent immunomodulatory therapy was higher (62% versus 42%; P = 0.048).
Conclusions And Clinical Importance:
These results suggest that the total number of antibacterial drug prescriptions, exposure to multiple drug classes (beta-lactams in particular) and concurrent immunomodulatory therapy may be associated with increased risk for acquisition of MRSP.
Insights
Previous antibacterial drug exposure, especially multiple classes like beta-lactams, and immunomodulatory therapy may increase the risk of meticillin-resistant Staphylococcus pseudintermedius (MRSP) pyoderma in dogs.
Area of Science:
- Veterinary Dermatology
- Antimicrobial Resistance
- Canine Health
Background:
- Meticillin-resistant Staphylococcus pseudintermedius (MRSP) poses a significant threat to animal health.
- Prior exposure to antibiotics is linked to the development of meticillin-resistant staphylococcal strains.
Purpose of the Study:
- To identify factors associated with prior antimicrobial drug use in dogs with MRSP pyoderma.
- To compare risk factors between MRSP and meticillin-sensitive S. pseudintermedius (MSSP) pyoderma cases.
Main Methods:
- Retrospective review of medical records for dogs diagnosed with S. pseudintermedius pyoderma (MRSP or MSSP).
- Inclusion criteria required a 12-month to 3-year drug history prior to diagnosis.
- Cases included MRSP (n=53) and MSSP (n=45) pyoderma diagnoses.
Main Results:
- Nearly all MRSP (98%) and MSSP (93%) cases had prior antibacterial drug exposure.
- MRSP cases showed significantly higher numbers and variety of antibacterial drug prescriptions compared to MSSP cases.
- MRSP cases were more likely to have received beta-lactam drugs and concurrent immunomodulatory therapy.
Conclusions:
- Increased total antibacterial drug prescriptions are associated with MRSP acquisition.
- Exposure to multiple antibiotic classes, particularly beta-lactams, may elevate MRSP risk.
- Concurrent immunomodulatory therapy appears to be a risk factor for MRSP pyoderma.
Related Concept Videos
01:25Clinical Significance of Antibiotic Resistance
01:25Mechanism of Antibiotic Resistance in MRSA
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:23Inhibitors of Gram-positive Cell Wall Synthesis
01:29Staphylococcal Skin Infections
01:31Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...