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Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

7.5K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription01:17

Transcription

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Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
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Transcription Factors02:16

Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Elongation Factors02:35

Transcription Elongation Factors

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Transcription Elongation Factors02:35

Transcription Elongation Factors

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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
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In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
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DsTRD: Danshen Transcriptional Resource Database.

Yuxuan Shao1, Jiabo Wei1, Fangli Wu1

  • 1Institute of Bioengineering, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, 310018, China.

Plos One
|February 25, 2016
PubMed
Summary
This summary is machine-generated.

A new Danshen Transcriptional Resource Database (DsTRD) was developed for Salvia miltiorrhiza research. This resource aids gene cloning and functional analysis by providing access to transcribed sequences and expression data.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Plant Science

Background:

  • Salvia miltiorrhiza is a vital medicinal plant with limited genomic resources hindering research.
  • Lack of genome sequences and expressed sequence tags restricts gene cloning and functional studies.

Purpose of the Study:

  • To develop a comprehensive transcript database for Salvia miltiorrhiza.
  • To facilitate sequence browsing, searching, and alignment for researchers.

Main Methods:

  • Assembled 76,531 transcribed sequences from 12 RNA-Seq transcriptomes.
  • Annotated transcripts using bioinformatics methods, including protein-coding RNAs, lncRNAs, and small RNAs.
  • Calculated tissue expression levels for each transcript.

Main Results:

  • Developed the Danshen Transcriptional Resource Database (DsTRD).
  • DsTRD contains annotated transcribed sequences and tissue-specific expression data.
  • The database is accessible online for public use.

Conclusions:

  • DsTRD significantly enhances research accessibility for Salvia miltiorrhiza.
  • The database supports gene cloning and functional analysis in this medicinal plant.