Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Establishment of pediatric neuroblastoma cell line and its resistance mechanism to lorlatinib].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2026

Same author

Repeated sublethal photodynamic inactivation does not increase biofilm formation or induce resistance in Acinetobacter baumannii.

Photodiagnosis and photodynamic therapy·2026

Same author

[Cytoreductive surgery in the management of recurrent or metastatic gastrointestinal stromal tumors: a retrospective analysis from a single-center experience].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026

Same author

[Development and validation of a risk prediction model for cardiogenic shock occurrence in acute myocardial infarction].

Zhonghua yi xue za zhi·2025

Same author

[A case of calcium pyrophosphate deposition disease with crowned dens syndrome].

Zhonghua nei ke za zhi·2025

Same author

[Comparation of the performance of different cardiovascular risk models in predicting cardiovascular diseases risk among Chinese patients with rheumatoid arthritis].

Zhonghua yi xue za zhi·2025

Search research articles

Related Experiment Video

Updated: Mar 25, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Developmental methylation pattern regulates porcine GPR120 expression.

H M Wang¹, J D Ma¹, L Jin¹

¹Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.

Genetics and Molecular Research : GMR

|February 25, 2016

Summary

This summary is machine-generated.

DNA methylation regulates G protein-coupled receptor 120 (GPR120) expression in porcine adipose tissue. Methylation of CpG islands in GPR120

More Related Videos

Targeted DNA Methylation Analysis by Next-generation Sequencing

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

Related Experiment Videos

Last Updated: Mar 25, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Targeted DNA Methylation Analysis by Next-generation Sequencing

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

Area of Science:

Epigenetics
Molecular Biology
Animal Science

Background:

DNA methylation is a key epigenetic mechanism regulating gene transcription, particularly at CpG islands (CGIs).
G protein-coupled receptor 120 (GPR120) is an omega-3 fatty acid receptor involved in lipogenesis and adipose tissue development.

Purpose of the Study:

To investigate the role of DNA methylation in regulating G protein-coupled receptor 120 (GPR120) expression in porcine adipose tissue.
To identify and analyze CpG islands within the GPR120 gene and their methylation status.

Main Methods:

Prediction of CpG islands (CGIs) in the GPR120 genomic sequence.
MassArray analysis to determine the methylation status of predicted CGIs.
Correlation analysis between GPR120 expression and adipose tissue development.

Main Results:

GPR120 is highly expressed in porcine mature adipose tissue and positively correlated with adipose tissue development (r = 0.86, P < 0.01).
Five CGIs were identified in the GPR120 gene, exhibiting significantly different methylation states (P(CGI) < 0.01).
DNA methylation in the GPR120 5'-untranslated and first exon regions negatively regulates its expression.

Conclusions:

Epigenetic regulation via DNA methylation plays a significant role in controlling GPR120 expression in porcine adipose tissue.
Understanding GPR120 DNA methylation provides insights into adipose tissue development and lipogenesis regulation.