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Relationship between 5-HTTLPR polymorphism and post-stroke depression.

W Y Guo1, Z H Zhang2, J L Mu3

  • 1Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang, Henan, China.

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The serotonin transporter gene

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Post-stroke depression (PSD) is a significant mental health issue.
  • The serotonin transporter gene, specifically the 5-HTTLPR polymorphism, is implicated in depressive disorders.

Purpose of the Study:

  • To investigate the association between the serotonin transporter-linked polymorphic region (5-HTTLPR) and post-stroke depression (PSD) in a Han Chinese population.

Main Methods:

  • Genotyping of the 5-HTTLPR in 199 PSD patients and 202 non-PSD controls.
  • Comparison of genotype and allele frequencies between the two groups.

Main Results:

  • The SS genotype frequency was significantly higher in the PSD group compared to the non-PSD group.
  • The LL genotype frequency was significantly higher in the non-PSD group compared to the PSD group (P < 0.01).

Conclusions:

  • A positive association exists between 5-HTTLPR and PSD in the Han Chinese population.
  • This study provides genetic evidence supporting susceptibility to PSD.