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Characterization of the down-regulated genes identified in preeclampsia placenta
1a Department of Obstetrics and Gynecology , Nara Medical University , Nara , Japan.
Objectives:
We focus our attention on placental genes that are repressed in preeclampsia.
Methods:
A search was conducted through the online PubMed database.
Results:
A majority of the down-regulated genes appear to be evolved as the defense and protective mechanism for the mother, namely maternal fitness genes. A half of the down-regulated genes are also located within and in close proximity to known imprinted genes.
Conclusion:
Preeclampsia may be associated with either: (1) down-regulated expression of genes located in close proximity to known imprinted genes, (2) an imbalance in the maternal-fetal genetic response, or (3) an interaction of the two.
