Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.1K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
3.8K
MicroRNAs01:22

MicroRNAs

24.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K
MicroRNAs01:22

MicroRNAs

4.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

12.0K
12.0K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-oxalate diet-induced kidney injury impairs AVF remodeling via hypertension, endothelial damage, and immune activation.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same author

Zigzag persistence for coral reef resilience using a stochastic spatial model.

Journal of the Royal Society, Interface·2023
Same author

Repeatability and reproducibility of cardiac manganese-enhanced magnetic resonance imaging.

Scientific reports·2023
Same author

Acute Pleurisy in Horses.

The Journal of comparative medicine and veterinary archives·2022
Same author

The Pathogenesis of Quinine Pneumonic Emphysema.

The Journal of comparative medicine and veterinary archives·2022
Same author

Open-joint.

The Journal of comparative medicine and veterinary archives·2022

Related Experiment Video

Updated: Mar 25, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K

lncRNA/MicroRNA interactions in the vasculature.

M D Ballantyne1,2, R A McDonald1, A H Baker1

  • 1Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.

Clinical Pharmacology and Therapeutics
|February 25, 2016
PubMed
Summary

Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) interact in vascular disease. Understanding these lncRNA-miRNA networks is crucial for developing new diagnostic and therapeutic strategies.

More Related Videos

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.4K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

2.1K

Related Experiment Videos

Last Updated: Mar 25, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.4K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

2.1K

Area of Science:

  • Molecular Biology
  • Vascular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are well-studied for their roles in vascular processes like angiogenesis and apoptosis.
  • The molecular mechanisms and functions of long noncoding RNAs (lncRNAs) in vascular biology are less understood.
  • Emerging research highlights the intricate interplay between lncRNAs and miRNAs.

Purpose of the Study:

  • To explore the regulatory interactions between lncRNAs and miRNAs in vascular pathophysiology.
  • To elucidate how lncRNAs influence miRNA function and vice versa.
  • To lay the groundwork for novel diagnostic and therapeutic strategies targeting lncRNA-miRNA networks.

Main Methods:

  • Literature review and synthesis of current research on lncRNA-miRNA interactions.
  • Analysis of molecular mechanisms, including lncRNAs acting as miRNA sponges and miRNAs regulating lncRNA stability.
  • Examination of the impact of these interactions on vascular cell functions.

Main Results:

  • lncRNAs can act as endogenous sponges, sequestering miRNAs and modulating gene expression.
  • miRNAs can bind to lncRNAs, affecting their stability and regulatory functions.
  • These complex regulatory networks significantly impact vascular pathophysiology.

Conclusions:

  • The interaction between lncRNAs and miRNAs represents a critical regulatory layer in vascular biology.
  • Further detailed investigation into these lncRNA-miRNA-mediated interactions is necessary.
  • Understanding these networks holds promise for future vascular disease diagnostics and therapeutics.