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Daptomycin for Children in Clinical Practice Experience

Silvia Garazzino1, Elio Castagnola, Maria Di Gangi

  • 1From the *Department of Paediatrics, University of Turin, AOU Città della Salute e della Scienza di Torino, Turin, Italy; †Infectious Diseases Unit and Laboratory of Microbiology (RB), Istituto Giannina Gaslini, Genoa, Italy; ‡Malattie Infettive Pediatriche, Ospedale dei Bambini "G.Di Cristina"-A.R.N.A.S. Palermo, Palermo, Italy; §Department of Sciences for Health promotion and Mother and Child Care "Giuseppe D'Alessandro," University of Palermo, Palermo, Italy; ¶Department of Paediatric Medicine, Paediatric and Infectious Diseases Unit, Children Hospital Bambino Gesù, IRCCS, Rome, Italy; ‖Department of Paediatrics, Azienda Ospedaliero-Universitaria "Santa Maria della Misericordia," Udine, Italy; **Paediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; ††University Department of Paediatrics, Unit of Immune and Infections Disease, Bambino Gesu' Children's Hospital, Rome Italy; and ‡‡Department of Sciences for Woman and Child's Health, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.

The Pediatric Infectious Disease Journal
|February 25, 2016
PubMed

Insights

Daptomycin is generally well-tolerated in children, even for extended periods. This study found few adverse events in pediatric patients receiving daptomycin treatment.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Clinical Therapeutics

Background:

  • Limited data exist regarding daptomycin's efficacy and safety in pediatric populations.
  • Daptomycin is a lipopeptide antibiotic used for Gram-positive bacterial infections.

Purpose of the Study:

  • To evaluate the safety and tolerability of intravenous daptomycin in children.
  • To assess daptomycin's use in a real-world pediatric clinical setting.

Main Methods:

  • A multicenter, retrospective study was conducted.
  • Data from 46 children treated with intravenous daptomycin were analyzed.
  • Mean dosage was 7.0 mg/kg/d for a median of 14 days.

Main Results:

  • Three children experienced adverse events potentially linked to daptomycin.
  • The antibiotic was generally well-tolerated across the study cohort.
  • Prolonged treatment durations did not appear to increase adverse event rates.

Conclusions:

  • Intravenous daptomycin demonstrates a favorable safety profile in pediatric patients.
  • Daptomycin can be considered a viable treatment option for Gram-positive infections in children.
  • Further prospective studies could confirm these findings.

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