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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Cancer Prevention02:59

Cancer Prevention

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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Related Experiment Video

Updated: Mar 25, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Melanoma screening: A plan for improving early detection.

Richard Shellenberger1, Mohammed Nabhan1, Sweta Kakaraparthi1

  • 1a Internal Medicine Department, St. Joseph Mercy Hospital , Ann Arbor, MI, USA.

Annals of Medicine
|February 26, 2016
PubMed
Summary

Whole-body skin examinations by primary care physicians can detect malignant melanoma early. This screening approach supports reduced melanoma mortality, especially when initiated through primary care education.

Keywords:
Malignant melanoma epidemiologyearly detection improves outcomesprimary care awarenessresident educationwhole-body skin examination

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Area of Science:

  • Dermatology
  • Oncology
  • Public Health

Background:

  • Malignant melanoma is the fifth most common cancer in the US.
  • Incidence is rising, yet national screening guidelines are absent.
  • Melanoma mortality has not significantly improved recently.

Purpose of the Study:

  • To review evidence on whole-body skin examinations for early melanoma detection.
  • To assess the potential mortality benefit of melanoma screening.

Main Methods:

  • Systematic review of data from multiple databases (MEDLINE, PubMed, Cochrane).
  • Inclusion of epidemiologic data, case-control trials, and simulation models.
  • Data extraction using a dual extraction method.

Main Results:

  • Melanoma mortality is strongly linked to tumor thickness at diagnosis.
  • Evidence supports whole-body skin examinations for early detection.
  • A German trial showed reduced melanoma-specific mortality with screening.

Conclusions:

  • Physician-performed whole-body skin exams aid early melanoma detection and reduce mortality.
  • A lack of randomized trials is a limitation in melanoma screening research.
  • Integrating skin cancer education into primary care residency programs is proposed to enhance screening.