Different evolutionary patterns of classical swine fever virus envelope proteins
Yan Li1, Zexiao Yang2, Mingwang Zhang1
1a College of Animal Science and Technology, Sichuan Agricultural University, Wenjiang, People's Republic of China.
Canadian Journal of Microbiology
|February 26, 2016
Summary
Classical swine fever virus envelope proteins E(rns) and E1 show functional divergence during evolution, unlike E2. These changes, particularly in E(rns), impact viral entry and immune evasion.
Area of Science:
- Virology
- Molecular Evolution
- Immunology
Background:
- Classical swine fever virus (CSFV) causes a highly contagious disease in pigs and wild boar.
- CSFV envelope proteins E(rns), E1, and E2 are crucial for viral attachment, entry, replication, and immune response.
Purpose of the Study:
- To investigate the genetic variations and evolutionary patterns of CSFV envelope proteins E(rns), E1, and E2.
- To understand the functional divergence of these proteins during CSFV evolution.
Main Methods:
- Analysis of genetic variations in CSFV envelope proteins.
- Comparative evolutionary analysis of E(rns), E1, and E2 proteins.
Main Results:
- Envelope proteins E(rns) and E1 exhibited significant functional divergence at specific amino acid sites, while E2 did not.
- Diversification in E(rns) and E1 occurred episodically, linked to major CSFV group separations.
- Key divergence sites in E(rns) were identified within the RNase domain and C-terminal extension, affecting innate immunity and host cell interactions.
Conclusions:
- CSFV envelope proteins have distinct evolutionary trajectories and functional roles.
- The identified functional divergence in E(rns) and E1 contributes to CSFV's adaptability and pathogenesis.
- Understanding these divergent roles is crucial for developing effective control strategies against classical swine fever.
Keywords:
adaptive diversificationclassical swine fever virusconfigurations distinctesdifferent patternsdiversification adaptativeenvelope proteinsprotéines de l’enveloppevirus de la peste porcine classiqueMore Related Videos
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