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Updated: Mar 25, 2026
Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Comparative analysis of full-time, half-time, and quarter-time myocardial ECG-gated SPECT quantification in
M Lecchi1, I Martinelli1, O Zoccarato2
1Nuclear Medicine Unit, Department of Health Sciences, University of Milan, San Paolo Hospital, Via Antonio di Rudini, 8, 20142, Milan, Italy.
Background:
The introduction of a camera-based dose-reduction strategy in myocardial perfusion imaging (MPI) clinical setting entails the definition of objective and reproducible criteria for establishing the amount of activity to be injected.
Aim:
The aim is to evaluate the impact of count statistics on the estimation of summed-scores (SS), end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF).
Methods:
Data rest/stress ECG-gated SPECT (2-day protocol and 8 MBq·kg-1) were acquired with Bright View gamma camera and Astonish algorithm for 40 normal-weight and 40 overweight patients. Assuming that count statistics of shorter acquisition time may simulate that of lower injected activity, three simultaneous scans (full-time, half-time, and quarter-time scans) were started at the same time but with different acquisition time/projection (30, 15 and 8 seconds).
Results:
A significant difference between SS values of half-time and quarter-time stress scans was found for overweight group (P = .006). Post hoc test showed significant differences for ESV (P < .05), EDV (P < .01) and EF (P < .05) between half-time and quarter-time scans for both patient groups.
Conclusions:
The reduction of the count-statistics to a quarter of the MPI reference influenced negatively the quantification in overweight patients. The decrease of radiopharmaceutical activity to 25% of the reference seems practicable for normal-weight patients, while it is more appropriate an activity reduction limited to 50% for overweight and obese patients.
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