Detection rate of serrated polyps and serrated polyposis syndrome in colorectal cancer screening cohorts: a European overview
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Summary
This summary is machine-generated.The prevalence of serrated polyps (SPs) in European screening programs varies, with a median detection rate of 19.5%. Establishing standardized reporting and assessment is crucial for colorectal cancer prevention.
Area Of Science
- Gastroenterology
- Oncology
- Public Health
Background
- Serrated polyps (SPs) are increasingly recognized as precursors to colorectal cancer.
- The actual prevalence of SPs across different screening populations remains largely unknown.
- Understanding SPs' detection rates is vital for refining colorectal cancer screening strategies.
Purpose Of The Study
- To evaluate the detection rates of various serrated polyp subtypes.
- To determine the prevalence of serrated polyposis syndrome (SPS) within European screening cohorts.
- To assess the variability in SP detection across different screening modalities.
Main Methods
- Analysis of prospectively collected European screening cohorts (≥1000 individuals).
- Exclusion of colonoscopies before 2009 and individuals under 50.
- Assessment of SP rates, histology, location, size, and calculation of number needed to screen (NNS).
- Evaluation of SPS rates in cohorts with follow-up data.
Main Results
- Median SP detection rate was 19.5% (range 15.1%-27.2%) across cohorts.
- Sessile serrated polyp rate was a median of 3.3% (range 2.2%-4.8%).
- Clinically relevant SPs (≥10mm or proximal >5mm) had a median rate of 4.6% (range 2.1%-7.8%).
- SP rates were similar in fecal occult blood test (FOBT) and colonoscopy screening cohorts.
- SPS prevalence ranged from 0% to 0.5%, increasing to 0.4%-0.8% after follow-up.
Conclusions
- Detection rates for serrated polyps (SPs) exhibit significant variability among screening cohorts.
- There is a need to establish uniform standards for reporting, detection, and histopathological assessment of SPs.
- The median SP detection rate identified in this study can inform the development of minimum screening standards for specific age and gender groups.