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Intracranial tumours in budgerigars.

A Suchy1, H Weissenböck1, P Schmidt2

  • 1a Institute of Pathology and Forensic Veterinary Medicine , Veterinary University Vienna , Veterinärplatz 1 , Vienna , A-1210 , Austria.

Avian Pathology : Journal of the W.V.P.A
|February 26, 2016
PubMed
Summary

This study examined 14 intracranial tumors in budgerigars, finding ependymal, choroid plexus, and pituitary tumors. Most tumors showed S-100 protein, while two pituitary carcinomas expressed growth hormone.

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Area of Science:

  • Veterinary Pathology
  • Avian Neoplasia
  • Immunohistochemistry

Background:

  • Intracranial tumors are a significant concern in avian medicine.
  • Comprehensive histological and immunohistochemical characterization of these tumors in budgerigars is limited.

Purpose of the Study:

  • To classify intracranial tumors in budgerigars using histological and immunohistochemical methods.
  • To investigate the expression of specific proteins and hormones within these neoplastic tissues.

Main Methods:

  • Retrospective analysis of 996 budgerigar cases with 14 intracranial tumors.
  • Histological examination and immunohistochemical staining for glial fibrillary acidic protein, vimentin, cytokeratin, neuron specific enolase, neurofilament-200, S-100 protein, and pituitary hormones (ACTH, MSH, prolactin, GH).

Main Results:

  • Tumor types identified: ependymoma (6), choroid plexus papilloma (1), adenohypophyseal tumors (6), and one unclassified tumor.
  • Positive S-100 protein staining in the cytoplasm of cells in most tumors.
  • Two adenohypophyseal carcinomas showed positive staining for growth hormone.
  • No immunoreactivity for GFAP, vimentin, cytokeratin, or NSE in neoplastic tissues.
  • Neurofilament-200 staining was positive in normal neuronal fibers but absent in tumor tissues.

Conclusions:

  • Budgerigar intracranial tumors exhibit diverse origins, including glial, ependymal, and pituitary.
  • S-100 protein is a potential marker for various intracranial tumors in budgerigars.
  • Growth hormone expression in pituitary carcinomas highlights specific endocrine involvement.