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Intracranial tumours in budgerigars
A Suchy1, H Weissenböck1, P Schmidt2
1a Institute of Pathology and Forensic Veterinary Medicine , Veterinary University Vienna , Veterinärplatz 1 , Vienna , A-1210 , Austria.
Avian Pathology : Journal of the W.V.P.A
|February 26, 2016
Summary
This study examined 14 intracranial tumors in budgerigars, finding ependymal, choroid plexus, and pituitary tumors. Most tumors showed S-100 protein, while two pituitary carcinomas expressed growth hormone.
Area of Science:
- Veterinary Pathology
- Avian Neoplasia
- Immunohistochemistry
Background:
- Intracranial tumors are a significant concern in avian medicine.
- Comprehensive histological and immunohistochemical characterization of these tumors in budgerigars is limited.
Purpose of the Study:
- To classify intracranial tumors in budgerigars using histological and immunohistochemical methods.
- To investigate the expression of specific proteins and hormones within these neoplastic tissues.
Main Methods:
- Retrospective analysis of 996 budgerigar cases with 14 intracranial tumors.
- Histological examination and immunohistochemical staining for glial fibrillary acidic protein, vimentin, cytokeratin, neuron specific enolase, neurofilament-200, S-100 protein, and pituitary hormones (ACTH, MSH, prolactin, GH).
Main Results:
- Tumor types identified: ependymoma (6), choroid plexus papilloma (1), adenohypophyseal tumors (6), and one unclassified tumor.
- Positive S-100 protein staining in the cytoplasm of cells in most tumors.
- Two adenohypophyseal carcinomas showed positive staining for growth hormone.
- No immunoreactivity for GFAP, vimentin, cytokeratin, or NSE in neoplastic tissues.
- Neurofilament-200 staining was positive in normal neuronal fibers but absent in tumor tissues.
Conclusions:
- Budgerigar intracranial tumors exhibit diverse origins, including glial, ependymal, and pituitary.
- S-100 protein is a potential marker for various intracranial tumors in budgerigars.
- Growth hormone expression in pituitary carcinomas highlights specific endocrine involvement.
