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Updated: Mar 25, 2026

06:15
Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Efficient continuous synthesis of high purity deep eutectic solvents by twin screw extrusion
D E Crawford1, L A Wright2, S L James1
1School of Chemistry and Chemical Engineering, Queen's University Belfast, 39 - 123 Stranmillis Road, Belfast, BT9 5AG, Northern Ireland, UK. s.james@qub.ac.uk.
Abstract:
Mechanochemical synthesis has been applied to the rapid synthesis of Deep Eutectic Solvents (DESs), including Reline 200 (choline chloride : urea, 1 : 2), in a continuous flow methodology by Twin Screw Extrusion (TSE). This gave products in higher purity and with Space Time Yields (STYs), four orders of magnitude greater than for batch methods.

