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Molecular imaging probes derived from natural peptides
C L Charron1, J L Hickey1, T K Nsiama2
1Department of Chemistry, The University of Western Ontario, London, Canada. lluyt@uwo.ca.
Natural Product Reports
|February 26, 2016
Summary
Natural peptides are vital in biological systems and disease. This review explores their discovery, receptors, and use in developing radiolabeled peptides for molecular imaging and therapeutics.
Area of Science:
- Biochemistry
- Pharmacology
- Molecular Imaging
Background:
- Peptides are crucial natural compounds with essential biological functions.
- Peptide receptors are linked to diseases like cancer, metabolic, and cardiovascular disorders.
- Natural peptides offer target specificity for diagnostic and therapeutic applications.
Purpose of the Study:
- To review natural peptides, their receptors, and derivatization into molecular imaging agents.
- To emphasize the design of radiolabeled peptides for diagnostic and therapeutic purposes.
- To highlight methods for discovering novel peptides without prior target or ligand knowledge.
Main Methods:
- Literature review of natural peptides and their applications up to 2015.
- Analysis of peptide derivatization strategies for molecular imaging.
- Exploration of peptide discovery methods.
Main Results:
- Natural peptides serve as valuable diagnostic and therapeutic agents due to receptor specificity.
- Radiolabeled peptides are a key focus for molecular imaging.
- Methods for discovering new peptides are discussed.
Conclusions:
- Natural peptides and their derivatives are important tools in medicine.
- Radiolabeling enhances peptide utility in molecular imaging.
- Novel peptide discovery is crucial for future advancements.
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