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Updated: Mar 25, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Modeling information flows in clinical decision support: key insights for enhancing system effectiveness.
Stephanie Medlock1, Jeremy C Wyatt2, Vimla L Patel3
1Department of Medical Informatics, University of Amsterdam, Amsterdam, The Netherlands s.k.medlock@amc.uva.nl.
Developing effective clinical decision support systems (CDSSs) requires understanding their impact on care and user interaction. This framework proposes a two-stream model to evaluate CDSS effectiveness beyond clinical outcomes.
Area of Science:
- Health Informatics
- Clinical Decision Support Systems
- Human-Computer Interaction
Background:
- A significant challenge in clinical decision support is defining system effectiveness.
- Current understanding lacks a comprehensive theory and model for clinical decisions and supporting systems.
- Existing research often treats clinical decision-support systems (CDSSs) monolithically.
Purpose of the Study:
- To outline a theoretical framework for understanding clinical decision support.
- To propose a two-stream model for information flow within CDSSs.
- To redefine the measurement of CDSS effectiveness.
Main Methods:
- Presentation of a two-stream model: the clinical stream (patient reasoning) and the cognitive-behavioral stream (user reasoning).
- Proposal for a multidimensional approach to measuring CDSS effectiveness.
- Emphasis on differentiating CDSSs based on system attributes, users, and decision context.
Main Results:
- The proposed framework models information flow in CDSSs through clinical and cognitive-behavioral streams.
- "Effectiveness" of CDSSs is proposed to encompass impact on clinical care, system usage, work processes, and decision quality.
- A call for research to differentiate CDSSs based on specific attributes, users, and decision types.
Conclusions:
- A novel framework and model are presented to address the fundamental challenge of CDSS effectiveness.
- Measuring CDSS effectiveness requires a broader perspective beyond clinical outcomes, including user interaction and process impact.
- Future research should adopt a nuanced approach, analyzing CDSSs based on their specific characteristics and contexts for improved understanding and development.
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