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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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StudySearch: a web-based application for posting and searching clinical research studies.

Blair Gonsenhauser1, Rose Hallarn1, Daniel Carpenter2

  • 1Center for Clinical and Translational Science at The Ohio State University, Columbus, Ohio, USA.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|February 26, 2016
PubMed
Summary

StudySearch is a web-based platform that lists IRB-approved research studies seeking participants. This tool aims to improve participant recruitment for clinical research by providing a searchable database.

Keywords:
Clinical ResearchInformaticsTranslational Medical Research

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Area of Science:

  • Clinical and translational research
  • Biomedical informatics
  • Research study recruitment

Background:

  • Participant accrual is essential for advancing clinical research.
  • Low participant recruitment and enrollment persist as significant challenges.
  • A publicly accessible and searchable platform is needed to connect studies with potential participants.

Purpose of the Study:

  • To introduce StudySearch, a web-based application designed to list IRB-approved research protocols actively recruiting participants.
  • To provide a centralized, easily accessible, and searchable resource for individuals interested in participating in clinical research.
  • To facilitate participant accrual by improving the visibility of ongoing studies.

Main Methods:

  • StudySearch is a web-based application developed by the Center for Clinical and Translational Science (CCTS).
  • It lists IRB-approved research studies with basic descriptive information: title, purpose, eligibility criteria, and contact details.
  • Studies are added either automatically via ClinicalTrials.gov or manually submitted by researchers, with iterative language refinement by CCTS staff.

Main Results:

  • Deployed in January 2011 at The Ohio State University (OSU), StudySearch currently lists approximately 200 studies.
  • The platform attracts around 1500 unique visitors per month.
  • The open-source application is available for national use, serving as a recruitment toolkit.

Conclusions:

  • StudySearch effectively addresses the challenge of low participant recruitment by offering a centralized and searchable database.
  • The platform enhances the visibility of clinical research studies, aiding both researchers and potential participants.
  • Its open-source nature allows for wider adoption and contributes to the advancement of clinical and translational research nationwide.