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Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Wide-field optical coherence tomography based microangiography for retinal imaging.

Qinqin Zhang¹, Cecilia S Lee², Jennifer Chao²

¹University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA.

Scientific Reports

|February 26, 2016

Summary

This study introduces wide-field optical coherence tomography angiography (OCTA) for detailed retinal imaging without dyes. This advanced OCTA technology offers high-resolution, broad retinal views for improved disease diagnosis.

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Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Optical coherence tomography angiography (OCTA) enables contrast-free evaluation of retinal vasculature.
Current OCTA limitations include restricted field of view, hindering comprehensive retinal disease assessment.
High-definition, wide-field imaging is crucial for sophisticated retinal disease monitoring and diagnosis.

Purpose of the Study:

To report a novel wide-field OCTA system with motion tracking for enhanced retinal vascular imaging.
To demonstrate the clinical feasibility and diagnostic utility of this advanced OCTA technology.
To showcase the capability of imaging over 60 degrees of retina with high definition and resolution.

Main Methods:

Development and implementation of OCTA with motion tracking using an auxiliary real-time line scan ophthalmoscope.
Acquisition of wide-field, high-resolution images of retinal vasculature in patients.
Clinical demonstration across six illustrative cases of retinal diseases.

Main Results:

Successful imaging of functional retinal vasculature over 60 degrees with high definition and resolution.
Detailed visualization of microvasculature at all retinal levels in both normal and diseased states.
Demonstrated superior resolution compared to traditional fluorescein angiography in case studies.

Conclusions:

Wide-field OCTA with motion tracking is clinically feasible for imaging retinal vasculature.
This technology provides unprecedented detail of vascular involvement in retinal diseases.
Wide-field OCTA represents a significant advancement, enhancing the clinical utility of OCT technology.