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Decreased Numbers of CD57+CD3- Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum

Dario Siniscalco¹, Tatjana Mijatovic², Eugene Bosmans²

¹Department of Experimental Medicine, Second University of Naples, Naples, Italy Centre for Autism - La Forza del Silenzio, Caserta, Italy Cancellautismo - Non-profit Association for Autism Care, Florence, Italy dariosin@uab.edu.

In Vivo (Athens, Greece)

|February 26, 2016

Summary

Children with autism spectrum disorder (ASD) often show reduced natural killer cells (CD57(+)CD3(-)). This immune cell reduction may indicate dysfunction and contribute to chronic inflammation in ASD.

Keywords:

Autism CD57+CD3− lymphocytes HNK-1 immune dysfunction

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Area of Science:

Immunology
Neurodevelopmental Disorders
Pediatrics

Background:

Autism spectrum disorders (ASD) are complex neurodevelopmental conditions.
Immune system abnormalities are increasingly recognized in ASD.
Understanding immune dysregulation is crucial for ASD research.

Purpose of the Study:

To investigate natural killer (NK) cells as a potential marker for immune dysfunction in ASD.
To evaluate the CD57(+)CD3(-) lymphocyte subpopulation in children with ASD.

Main Methods:

Analysis of fresh peripheral blood samples from children diagnosed with autism.
Utilized three-color flow cytometry to quantify CD57(+)CD3(-) lymphocytes.

Main Results:

A significant reduction in the count of CD57(+)CD3(-) lymphocytes was observed in a notable number of children with ASD.
This finding suggests a potential quantitative immune abnormality in the studied population.

Conclusions:

The peripheral CD57(+)CD3(-) cell count is frequently below normal ranges in children with ASD.
This reduction may indicate a defect in immune counter-regulation, potentially contributing to chronic inflammation in ASD.