Related Experiment Video
Updated: Mar 25, 2026
Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
Published on: October 17, 2025
Decreased Numbers of CD57+CD3- Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum
Dario Siniscalco1, Tatjana Mijatovic2, Eugene Bosmans2
1Department of Experimental Medicine, Second University of Naples, Naples, Italy Centre for Autism - La Forza del Silenzio, Caserta, Italy Cancellautismo - Non-profit Association for Autism Care, Florence, Italy dariosin@uab.edu.
Background/Aim:
Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of this malady. The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD.
Materials And Methods:
Three-color flow cytometry-based analysis of fresh peripheral blood samples from children with autism was utilized to measure CD57(+)CD3(-) lymphocytes.
Results:
A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism.
Discussion And Conclusion:
We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.
Related Concept Videos
01:19Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
01:21Introduction to Innate and Adaptive Immunity
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
01:38What is the Immune System?
01:22Gut-Brain Axis
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...