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Updated: Mar 25, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
Published on: January 2, 2012
Comment on "Cortical folding scales universally with surface area and thickness, not number of neurons"
Eric Lewitus1, Iva Kelava2, Alex T Kalinka3
1Institut de Biologie, École Normale Supérieure, Paris, France. lewitus@biologie.ens.fr huttner@mpi-cbg.de.
Abstract:
Mota and Herculano-Houzel (Reports, 3 July 2015, p. 74) assign power functions to neuroanatomical data and present a model to account for evolutionary patterns of cortical folding in the mammalian brain. We detail how the model assumptions are in conflict with experimental and observational work and show that the model itself does not accurately fit the data.
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