Related Experiment Video
Updated: Mar 25, 2026

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
Published on: December 26, 2017
Immune Globulin Intravenous: Myasthenia Gravis (Acute Exacerbation)
Joyce A Generali1, Dennis J Cada2
1Editor-in-Chief, Hospital Pharmacy , and Clinical Professor, Emeritus, Department of Pharmacy Practice, University of Kansas, School of Pharmacy , Kansas City/Lawrence, Kansas ,
This guide helps healthcare professionals find and evaluate off-label drug uses not approved by the US Food and Drug Administration (FDA). It aids in determining the rationality of these uses in patient care scenarios using published literature.
Area of Science:
- Pharmacy
- Pharmacology
- Evidence-Based Medicine
Background:
- Off-label drug use is common in clinical practice.
- Information on unapproved drug indications can be fragmented.
- Practitioners need reliable resources to assess off-label drug efficacy and safety.
Purpose of the Study:
- To introduce a resource for off-label drug information.
- To guide healthcare professionals in evaluating off-label drug uses.
- To facilitate evidence-based decision-making for unapproved indications.
Main Methods:
- Extraction of information from the "Off-Label Drug Facts" publication.
- Literature review to identify published studies on off-label drug uses.
- Guidance on assessing the rationality of specific off-label uses.
Main Results:
- Provides a practitioner-oriented resource for off-label drug information.
- Enables quick identification of published studies on unapproved drug uses.
- Offers references for comprehensive literature review.
Conclusions:
- "Off-Label Drug Facts" supports informed clinical decision-making.
- Enhances the rational use of medications in patient care.
- Facilitates evidence-based practice for unapproved drug indications.
Related Concept Videos
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Myocarditis III: Medical Management
Myocarditis IV: Nursing Management
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Pharmaceutical Poisoning: Treatment Strategies

