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The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region
D W Burt1, L J Mullins, H George
1Department of Biochemistry, University of Leicester, U.K.
Gene
|December 7, 1989
Abstract:
The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns. The entire nucleotide sequence of the Ren-1d gene has been determined and the 5'-flanking regions of the three genes, Ren-1c, Ren-1d and Ren-2d, have been compared. The significance of several potential regulatory signals found in the DNA is discussed.