Rubiaceae-Type Cyclopeptides from Galianthe thalictroides
Patrícia O Figueiredo1, Maria de Fatima C Matos2, Renata T Perdomo2
1Instituto de Química, Universidade Federal de Mato Grosso do Sul , Campo Grande, MS 79074-460, Brazil.
Abstract:
Two Rubiaceae-type cyclopeptides, 6-O-methylbouvardin (1) and the new cyclopeptide 5β-hydroxy-RA-III (2), were isolated from the roots of Galianthe thalictroides. Employing the sulforhodamine B assay, compounds 1 and 2 were tested in vitro against three cancer cell lines--786-0 (kidney carcinoma), PC-3 (prostate carcinoma), and HT-29 (colon carcinoma)--and showed GI50 values ranging from 0.06 to 1.80 μg mL(-1). This is the first report on the isolation of Rubiaceae-type cyclopeptides from a genus other than Rubia or Bouvardia.
Related Concept Videos
Red Algae
The Calvin Benson Cycle
Cycloaddition Reactions: Overview
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Cycloaddition Reactions: MO Requirements for Thermal Activation
Cell Signaling in Plants


