Related Experiment Video
Updated: Mar 25, 2026
08:38
A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy
Published on: April 30, 2015
15.7K
Sinusoidal obstruction syndrome (SOS): A light and electron microscopy study in human liver
C P H Vreuls1, A Driessen2, S W M Olde Damink3
1Department of Pathology, Maastricht University Medical Centre, Maastricht, The Netherlands; Department of Pathology, Amphia Hospital, Breda, The Netherlands.
Micron (Oxford, England : 1993)
|February 26, 2016
Summary
Oxaliplatin-induced sinusoidal obstruction syndrome (SOS) in humans involves endothelial cell detachment. This study confirms findings from rat models in human liver biopsies, detailing key pathological features.
Area of Science:
- Hepatology
- Oncology
- Pathology
Background:
- Oxaliplatin is a key chemotherapy for colorectal liver metastases.
- Oxaliplatin is known to cause sinusoidal obstruction syndrome (SOS).
- Current understanding of SOS pathophysiology relies on animal models.
Purpose of the Study:
- To comprehensively investigate the features of human sinusoidal obstruction syndrome (SOS).
- To utilize both light microscopy (LM) and electron microscopy (EM) for detailed analysis.
- To compare human SOS findings with existing data from rat models.
Main Methods:
- Analysis of wedge liver biopsies from patients undergoing partial hepatectomy for colorectal liver metastases.
- Perfusion fixation and processing of biopsies for LM and EM.
- Selection and detailed EM study of SOS lesions in 30 patients (28 treated with oxaliplatin).
Main Results:
- SOS lesions were identified in 64% (18/28) of oxaliplatin-treated patients.
- Microscopic findings revealed sinusoidal endothelial cell detachment from the space of Disse.
- Enlargement of the space of Disse with erythrocyte presence was observed via EM.
Conclusions:
- Human SOS is characterized by sinusoidal endothelial cell detachment.
- The space of Disse is enlarged and contains erythrocytes in human SOS.
- These findings validate previous observations from rat models in a clinical context.
Related Concept Videos
01:27Liver Histology
10.1K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
10.1K
01:17Gross Anatomy of the Liver
2.6K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.6K