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Predictors of Acute Kidney Injury in Cardiac Transplantation
R Tjahjono1, M Connellan2, E Granger3
1Faculty of Medicine, The University of New South Wales, Sydney, Australia.
Transplantation Proceedings
|February 27, 2016
Summary
Acute kidney injury (AKI) is common after cardiac transplantation, affecting 58.6% of patients. Risk factors include longer bypass times and transfusions, with AKI linked to increased mortality.
Area of Science:
- Nephrology
- Cardiology
- Transplantation Medicine
Background:
- Acute kidney injury (AKI) significantly increases morbidity and mortality.
- Limited data exists on AKI incidence following cardiac transplantation.
Purpose of the Study:
- To determine the incidence of AKI after orthotopic cardiac transplantation.
- To identify risk factors associated with AKI in this patient population.
Main Methods:
- Retrospective analysis of 111 cardiac transplant recipients from 2009-2014.
- Evaluation of pre-, intra-, and post-operative characteristics.
- Utilized RIFLE criteria for AKI diagnosis.
Main Results:
- AKI occurred in 58.6% of patients; 38 required dialysis.
- Risk factors included longer cardiopulmonary bypass, increased blood product transfusions, and re-exploration for bleeding.
- AKI was associated with longer inotropic support, ventilation duration, and higher mortality.
Conclusions:
- AKI is prevalent and prognostically significant after cardiac transplantation.
- Targeting modifiable risk factors may help prevent AKI.
- Further strategies are needed to conclusively prevent AKI post-cardiac surgery.
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