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Imidazole Derivatives as Potential Therapeutic Agents
Archana Sharma1, Vipin Kumar, Rajeev Kharb
1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India. archanakuk@gmail.com.
Current Pharmaceutical Design
|February 27, 2016
Summary
Imidazole derivatives are crucial in biological systems and exhibit significant pharmacological potential, particularly as anti-infective agents. This review details their synthesis and biological activities, offering insights for future research.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Pharmacology
Background:
- The imidazole ring is a fundamental and widespread structure in biological systems.
- Imidazole derivatives possess diverse and significant pharmacological activities, driving extensive research.
Purpose of the Study:
- To review the chemistry and synthetic methodologies of imidazoles.
- To discuss the biological activity profiles of imidazole derivatives reported between 2000 and 2015.
Main Methods:
- Systematic literature survey focusing on imidazole chemistry and synthesis.
- Detailed discussion of biological activities based on published research.
Main Results:
- Imidazole derivatives demonstrate notable anti-infective activity.
- Various synthetic approaches, including click chemistry, are applicable to imidazoles.
Conclusions:
- Imidazole derivatives hold significant promise as anti-infective agents.
- This review provides valuable information for researchers exploring the imidazole scaffold.
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