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Related Concept Videos

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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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Related Experiment Video

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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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Mouse models for studying prostate cancer bone metastasis.

Jinlu Dai1, Janine Hensel2, Ning Wang3

  • 1Department of Urology, University of Michigan , Ann Arbor, MI, USA.

Bonekey Reports
|February 27, 2016
PubMed
Summary

Prostate cancer bone metastasis has poor outcomes due to unknown mechanisms. This study details xenograft mouse models to investigate prostate cancer bone metastasis biology using various tumor inoculation methods.

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Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
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Area of Science:

  • Oncology
  • Cancer Biology
  • Animal Models

Background:

  • Prostate cancer bone metastasis significantly worsens patient prognosis.
  • The underlying mechanisms of bone metastasis are poorly understood.
  • A lack of suitable animal models hinders research.

Purpose of the Study:

  • To provide detailed protocols for established xenograft mouse models.
  • To facilitate the study of prostate cancer bone metastasis.
  • To explore the biological mechanisms of bone metastasis.

Main Methods:

  • Description of step-by-step protocols for xenograft mouse models.
  • Utilizing intraosseous, intracardiac, intravenous, and orthotopic tumor inoculation routes.
  • Focus on creating and analyzing models of prostate cancer bone metastasis.

Main Results:

  • Established protocols for reproducible xenograft models.
  • Demonstrated utility of different inoculation routes for studying metastasis.
  • Provided a framework for investigating bone metastasis biology.

Conclusions:

  • Xenograft mouse models are crucial for studying prostate cancer bone metastasis.
  • The described protocols enable further research into metastasis mechanisms.
  • These models offer valuable insights into the biology of bone metastasis.