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Coronary endothelial dysfunction is associated with increased risk of venous thromboembolism

Megha Prasad1, Robert McBane1, Martin Reriani1

  • 1Division of Cardiovascular Disease, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Thrombosis Research
|February 27, 2016
PubMed

Insights

Coronary endothelial dysfunction (CED) predicts venous thromboembolism (VTE) in patients with coronary atherosclerosis. This suggests endothelial injury may disrupt vascular hemostasis, increasing VTE risk.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Thrombosis Research

Background:

  • Normal endothelial function is crucial for natural anticoagulation.
  • Endothelial dysfunction is a potential risk factor for venous thromboembolism (VTE).
  • Coronary atherosclerosis patients without critical stenoses may have underlying endothelial dysfunction.

Purpose of the Study:

  • To determine if coronary endothelial dysfunction (CED) predicts the development of VTE.
  • To investigate the association between CED and VTE incidence in patients with coronary atherosclerosis.

Main Methods:

  • Evaluated coronary microvascular function in 502 patients with coronary atherosclerosis using intracoronary acetylcholine.
  • Defined coronary microvascular endothelial dysfunction as ≤50% increase in coronary blood flow.
  • Assessed VTE development via questionnaire after a median follow-up of 6.3 years.

Main Results:

  • Coronary endothelial dysfunction (CED) was present in 56% of patients.
  • Nine VTE events occurred in patients with CED, versus none in the control group (P=0.01).
  • Common risk factors included hypertension, diabetes, and hyperlipidemia.

Conclusions:

  • Coronary endothelial dysfunction (CED) is significantly associated with the future development of VTE.
  • Endothelial injury may contribute to VTE by disrupting vascular hemostasis.
  • CED could serve as a predictive marker for VTE in specific patient populations.
Abstract

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