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Cryopreserved Arterial Allografts and ABO and Rhesus Compatibility
Nellie Della Schiava1, Jean-Louis Mathevet1, Tarek Boudjelit2
1Department of Vascular and Endovascular Surgery, University Hospital of Lyon, Lyon Cedex 03, France; Faculté de Médecine Laennec, Université Claude Bernard - Lyon 1, Villeurbanne, France.
Background:
Arterial cryopreserved allografts are conduit of choice for arterial bypass in case of infection. They are sometimes submitted to accelerated degeneration: stenosis, thrombosis, or aneurysmal evolution. We hypothesized that ABO group and Rhesus compatibility could play a role in arterial cryopreserved allograft complications.
Methods:
Patients who benefit from allograft bypass from 2006 to 2011 were retrospectively compared, regarding ABO or rhesus compatibility and irregular agglutinins.
Results:
Seventy-two patients were included. Regarding ABO mismatch, there was no difference in terms of death (51% vs. 43%, P = 0.820), thrombosis (25% vs. 32%, P = 0.78), rupture (9% vs. 0%, P = 0.247), stenosis (3% vs. 12%, P = 0.331), aneurysmal degeneration (16% vs. 12%, P = 1), and 5 years of secondary patency rate (34% vs. 39%, P = 0.141). There was also no difference regarding Rhesus mismatch.
Conclusions:
Allograft degeneration does not seem to be related to ABO mismatch. This degeneration could be related to another way of immunogenicity, particularly Human Leukocyte Antigen mismatch, and needs further exploration.
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