Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors

Debin Zeng1, Yuying Ma1, Rui Zhang1

  • 1State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, PR China.

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Amides can undergo either acid-catalyzed hydrolysis or base-promoted hydrolysis through a typical nucleophilic acyl substitution. Each hydrolysis requires severe conditions.
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