Related Experiment Video
Updated: Mar 25, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
910
Serum periostin in obstructive airways disease.
James Fingleton1, Irene Braithwaite2, Justin Travers3
1Medical Research Institute of New Zealand, Wellington, New Zealand Capital and Coast District Health Board, Wellington, New Zealand Victoria University of Wellington, Wellington, New Zealand james.fingleton@mrinz.ac.nz.
The European Respiratory Journal
|February 27, 2016
Summary
Serum periostin, a biomarker for type 2 inflammation in asthma, shows a skewed distribution in adults with airflow obstruction. Inhaled corticosteroid therapy significantly reduced periostin levels.
Area of Science:
- Respiratory Medicine
- Biomarkers
- Immunology
Background:
- Asthma is characterized by type 2 inflammation.
- Serum periostin is investigated as a potential biomarker for treatment response in asthma.
- Understanding periostin's role in airflow obstruction is crucial.
Purpose of the Study:
- To determine serum periostin distribution in adults with symptomatic airflow obstruction.
- To examine associations between periostin and type 2 biomarkers.
- To assess the impact of inhaled corticosteroids (ICS) on serum periostin levels.
Main Methods:
- Cross-sectional study of 386 adults (18-75 years) with wheeze/breathlessness.
- Serum periostin levels measured.
- Analysis of associations with exhaled nitric oxide, blood eosinophils, and total IgE.
- Intervention study in 49 ICS-naïve patients treated with budesonide.
Main Results:
- Serum periostin levels exhibited a right-skewed distribution (median 54.0 ng/mL).
- Periostin showed weak positive associations with exhaled nitric oxide, blood eosinophil count, and total IgE.
- ICS therapy significantly reduced serum periostin levels by -4.8 ng/mL.
Conclusions:
- Serum periostin distribution data is provided for adults with symptomatic airflow obstruction.
- Periostin has weak associations with established type 2 biomarkers.
- Inhaled corticosteroid treatment effectively reduces serum periostin levels in asthma.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.1K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.1K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.4K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.4K
01:20COPD: Pathogenesis and Clinical Features
2.2K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K
01:24Chronic Obstructive Pulmonary Disease
3.1K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.1K
01:31Osteoclasts in Bone Remodeling
4.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.7K