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Primary dapsone resistance in China.

J K Chen, S Y Wang, Y H Hou

    Leprosy Review
    |December 1, 1989
    PubMed
    Summary
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    Primary dapsone resistance in Mycobacterium leprae is a significant concern. Forty-four percent of tested strains from previously untreated leprosy patients exhibited resistance, with some showing high-degree resistance.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Dermatology

    Background:

    • Leprosy remains a global health challenge, particularly multibacillary forms.
    • Dapsone has been a cornerstone of leprosy treatment, making resistance a critical issue.

    Purpose of the Study:

    • To determine the prevalence of primary dapsone resistance in Mycobacterium leprae strains.
    • To characterize the degree of dapsone resistance in newly diagnosed patients.

    Main Methods:

    • Ninety-seven Mycobacterium leprae strains from untreated patients in China were collected.
    • Dapsone susceptibility was assessed using a mouse infection model.

    Main Results:

    • Testing was conclusive for 70 strains; 31 (44%) showed primary dapsone resistance.

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  • Most resistant strains exhibited low- or intermediate-degree resistance.
  • One-sixth of the resistant strains demonstrated high-degree resistance.

    • Conclusions:

    • A substantial proportion of leprosy strains exhibit primary dapsone resistance.
    • The presence of high-degree resistance warrants attention for treatment strategies.
    • Monitoring dapsone susceptibility is crucial for effective leprosy control.