Drug-Induced Metabolic Acidosis

Area of Science:

• Pharmacology
• Nephrology
• Internal Medicine

Background:

• Metabolic acidosis can result from diseases affecting acid-base balance or from certain medications.
• Drug-induced metabolic acidosis often presents with comorbid conditions and can have severe clinical outcomes.

Purpose of the Study:

• To review and categorize drugs causing metabolic acidosis based on their pathophysiological mechanisms.
• To enhance clinician awareness of drug-induced metabolic acidosis and its underlying causes.

Main Methods:

• Literature review focusing on drug-induced metabolic acidosis.
• Categorization of drugs by pathophysiological mechanisms.
• Analysis of individual drug characteristics contributing to metabolic acidosis.

Main Results:

• Identified a range of drugs capable of inducing metabolic acidosis.
• Detailed the various pathophysiological pathways through which drugs cause metabolic acidosis.
• Highlighted the importance of drug-specific characteristics in acidosis development.

Conclusions:

• Clinicians must be aware of drugs that can cause metabolic acidosis.
• Understanding the pathogenic mechanisms is essential for effective clinical management.
• This review provides a framework for classifying drug-induced metabolic acidosis.