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Updated: Mar 25, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Advances in understanding and managing bullous pemphigoid
Cathy Y Zhao1, Dedee F Murrell1
1Department of Dermatology, St George Hospital, Kogarah, Sydney, NSW 2217, Australia; University of New South Wales, Kensington, Sydney, NSW 2052, Australia.
Abstract:
Bullous pemphigoid (BP) is the commonest subtype of autoimmune blistering disease in most countries of the world. It occurs most frequently in elderly patients and is characterised clinically by large, tense blisters in the skin preceded by urticarial plaques and pruritus. Immunopathologically, it is characterised by autoantibodies directed against the 180 kD antigen (BP180) and the 230 kD antigen (BP230). New knowledge regarding BP is being continually uncovered. This article reviews the recent advances in BP, including newer diagnostic tests, standardised outcome measures and emerging therapeutic options, as well as the evidence supporting their use.
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