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Exercise training produces changes in free and conjugated catecholamines.

B A Bauer1, P J Rogers, T D Miller

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.

Medicine and Science in Sports and Exercise
|October 1, 1989
PubMed
Summary

Exercise training in dogs increases conjugated dopamine and norepinephrine in plasma. This suggests that the sulfation of catecholamines, important for regulating physiological responses, is enhanced by regular physical activity.

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Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007

Area of Science:

  • Veterinary Medicine
  • Exercise Physiology
  • Biochemistry

Background:

  • Previous studies indicated exercise training increases conjugated dopamine in canine plasma.
  • The effects of exercise training on conjugated norepinephrine and epinephrine in dogs remained largely uninvestigated.

Purpose of the Study:

  • To investigate the impact of a 12-week exercise training program on plasma concentrations of conjugated norepinephrine and epinephrine in dogs.
  • To compare changes in catecholamine profiles between trained and sedentary dogs.

Main Methods:

  • Fifteen dogs were allocated to either a 12-week training or sedentary group.
  • Acute exercise tests (5 min at 4 mph, 12% grade) were performed before and after the intervention period.
  • Plasma concentrations of free and conjugated catecholamines (norepinephrine, epinephrine, dopamine) were measured using high-performance liquid chromatography (HPLC) with electrochemical detection.

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Main Results:

  • Following training, resting plasma levels of free and conjugated dopamine, and conjugated norepinephrine significantly increased.
  • Acute exercise post-training led to increased free norepinephrine and decreased conjugated norepinephrine.
  • Sedentary dogs did not exhibit significant changes in resting catecholamines, and their response to acute exercise differed from trained dogs.

Conclusions:

  • Exercise training in dogs leads to elevated resting plasma concentrations of conjugated dopamine and norepinephrine.
  • The sulfation of catecholamines appears to increase as a consequence of exercise training.
  • Conjugated epinephrine levels did not show significant changes in response to training.