Related Experiment Video

Updated: Mar 25, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy

Natasha Banerjee1, Esha Sachdev2, Robert A Figlin3

  • 1Oncology, Cedars-Sinai Medical Center.

Cureus
|February 27, 2016
PubMed

Insights

Whole exome sequencing identified a rare BRAF mutation in metastatic renal cell carcinoma. Targeted BRAF inhibition therapy led to a positive clinical response, highlighting precision medicine

Area of Science:

  • Oncology
  • Genetics
  • Precision Medicine

Background:

  • Whole exome sequencing (WES) aids in identifying somatic mutations for personalized cancer treatment.
  • BRAF gene mutations are infrequently observed in renal cell carcinoma (RCC).
  • BRAF inhibitors are not a standard treatment for RCC due to the rarity of BRAF mutations.

Observation:

  • A patient with metastatic renal cell carcinoma presented with a rare BRAF gene mutation.
  • The patient received treatment with a BRAF inhibitor targeted therapy.

Findings:

  • The patient with BRAF-mutated metastatic renal cell carcinoma showed a significant clinical response to BRAF inhibition.
  • This response demonstrates the efficacy of targeted therapy in rare genetic contexts of RCC.

Implications:

  • This case highlights the critical role of precision medicine in managing rare cancer mutations.
  • It supports the use of comprehensive genomic profiling for guiding novel therapeutic strategies in oncology.
  • Further research into BRAF-targeted therapies for specific RCC subtypes may be warranted.
Keywords:
braf inhibitoroncologyprecision medicinerenal cell cancertargeted therapywhole genome sequencing

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