Related Experiment Video
Updated: Mar 25, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
The asthma prediction rule to decrease hospitalizations for children with asthma
Donald H Arnold1, Marion R Sills, Colin G Walsh
1aDivision of Emergency Medicine, Department of Pediatrics and Center for Asthma Research, Vanderbilt University School of Medicine, Nashville, Tennessee bSection of Emergency Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado cDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Insights
A new asthma prediction rule (APR) helps decide if children with asthma exacerbations need hospitalization. Developed using bedside data, it shows promise in reducing unnecessary hospital admissions.
Area of Science:
- Pediatric Emergency Medicine
- Clinical Decision Support Systems
- Respiratory Medicine
Background:
- Clinical decision-making for hospitalizing children with acute asthma exacerbations presents challenges.
- Existing research on prediction rules for pediatric asthma is limited.
Purpose of the Study:
- To review challenges in hospitalizing children with acute asthma exacerbations.
- To discuss the development, validation, and potential of the asthma prediction rule (APR).
- To explore how APR can support clinical decisions and reduce hospitalizations.
Main Methods:
- The asthma prediction rule (APR) was developed and internally validated.
- Predictor variables available before emergency department treatment were used.
- Clinically intuitive variables obtainable at the bedside were selected.
Main Results:
- The APR demonstrated good performance in predicting the 'need-for-hospitalization.'
- Key predictors for hospitalization included oxygen saturation on room air and expiratory phase prolongation.
- The rule was developed and validated using readily available clinical data.
Conclusions:
- The APR shows potential for clinical decision support in pediatric asthma exacerbations.
- External validation and impact analysis are necessary before widespread implementation.
- The APR aims to improve patient outcomes and potentially decrease unnecessary hospitalizations.
Purpose Of Review:
The aim of the present review was to discuss the challenges around clinical decision-making for hospitalization of children with acute asthma exacerbations and the development, internal validation, and future potential of the asthma prediction rule (APR) to provide meaningful clinical decision-support that might decrease unnecessary hospitalizations.
Recent Findings:
The APR was developed and internally validated using predictor variables available before treatment in the emergency department, and performed well to predict 'need-for-hospitalization.' Oxygen saturation on room air and expiratory phase prolongation were most strongly associated with need-for-hospitalization.
Summary:
Research on prediction rules in pediatric asthma is rare. We developed and internally validated the APR using clinically intuitive predictor variables that are available at the bedside. Before incorporation into electronic decision-support the APR must undergo external validation and an impact analysis to determine if use of this tool will change clinician behavior and improve patient outcomes.
Related Concept Videos
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma-IV: Nursing Management
First, in...
Asthma-I: Introduction
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
