Related Experiment Video
Updated: Mar 25, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
Microbes and the mind: emerging hallmarks of the gut microbiota-brain axis
Kylynda C Bauer1,2, Kelsey E Huus1,2, B Brett Finlay1,2,3
1Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Abstract:
The concept of a gut microbiota-brain axis has emerged to describe the complex and continuous signalling between the gut microbiota and host nervous system. This review examines key microbial-derived neuromodulators and structural components that comprise the gut microbiota-brain axis. To conclude, we briefly identify current challenges in gut microbiota-brain research and suggest a framework to characterize these interactions. Here, we propose five emerging hallmarks of the gut microbiota-brain axis: (i) Indistinguishability, (ii) Emergence, (iii) Bidirectional Signalling, (iv) Critical Window Fluidity and (5) Neural Homeostasis.
Related Concept Videos
Gut-Brain Axis
Introduction to the Human Microbiota
Functions of the Gut Microbiota
The Oral Microbiota
Development of Human Microbiota
Microbiota of the Large Intestine

