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Updated: Mar 25, 2026

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes
Published on: April 13, 2018
Consequences of aneuploidy in sickness and in health
Samuel D Rutledge1, Daniela Cimini1
1Department of Biological Sciences and Biocomplexity Institute, Virginia Tech, Blacksburg, VA 24061, USA.
Abstract:
A link between aneuploidy and miscarriage or cancer in humans has been known for a long time. However, only in recent years the development of experimental models of whole-chromosome aneuploidy has allowed investigators to take a closer look at how aneuploidy affects individual cells. Collectively, recent studies using these models have shown that aneuploidy induces transcriptomic and proteomic changes, chromosomal instability, and adaptation. In this article, we discuss the findings from these recent studies and present current and emerging models on how aneuploidy may be deleterious in certain contexts, but beneficial in others.
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