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Self non self discrimination within the immune system: a view from the bridge
J Urbain1, G Urbain-Vansanten, D De Wit
1Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode Saint Genèse.
Nephrologie
|January 1, 1989
Summary
This review explores immune self-tolerance mechanisms, including clonal deletion, anergy, and suppression. A new theory proposes self-presenting cells shape immune repertoire generation through self-antigen presentation.
Area of Science:
- Immunology
- Molecular Biology
- Autoimmunity
Background:
- Self-tolerance is crucial for preventing autoimmune diseases.
- Existing models explain aspects of self-tolerance but lack a unified framework.
- Mechanisms like clonal deletion, anergy, and suppression are key but incompletely understood.
Purpose of the Study:
- To review current concepts of immune self-tolerance mechanisms.
- To highlight the complexity and interplay of known tolerance phenomena.
- To propose a novel theory on immune repertoire generation.
Main Methods:
- Literature review of self-tolerance mechanisms.
- Conceptual analysis of clonal deletion, anergy, and suppression.
- Theoretical framework development for immune repertoire generation.
Main Results:
- Confirms the complexity and complementarity of clonal deletion, anergy, and suppression.
- Introduces the concept of 'self-presenting cells'.
- Proposes a new theory linking self-antigen presentation by these cells to immune repertoire generation.
Conclusions:
- Immune self-tolerance involves intricate, complementary mechanisms.
- Self-presenting cells and their role in self-antigen presentation offer a new perspective on immune repertoire development.
- This framework may advance understanding of autoimmunity and immune regulation.