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Self non self discrimination within the immune system: a view from the bridge
J Urbain1, G Urbain-Vansanten, D De Wit
1Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode Saint Genèse.
The author reviews the actual concepts on the mechanisms of self-tolerance. He underlines the complexity and the complementarity of the different phenomenons of clonal deletion, clonal anergy and suppression. In addition, he proposes a new theory on the generation of the immune repertoires based on the presentation of self-antigens by particular antigen-presenting cells, the self-presenting cells.
The author reviews the actual concepts on the mechanisms of self-tolerance. He underlines the complexity and the complementarity of the different phenomenons of clonal deletion, clonal anergy and suppression. In addition, he proposes a new theory on the generation of the immune repertoires based on the presentation of self-antigens by particular antigen-presenting cells, the self-presenting cells.