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Related Experiment Video

Updated: Mar 25, 2026

Low-Cost Automated Flight Intercept Trap for the Temporal Sub-Sampling of Flying Insects Attracted to Artificial Light at Night

Low-Cost Automated Flight Intercept Trap for the Temporal Sub-Sampling of Flying Insects Attracted to Artificial Light at Night

Published on: December 29, 2021

Catch me if you can.

Emilie Bourdonnay¹, Thomas Henry¹

¹CIRI-Centre International de Recherche en Infectiologie, Inserm U1111, Université Lyon 1, Ecole Normale Supérieure, CNRS UMR5308, Lyon, France.

|February 27, 2016

Summary

This summary is machine-generated.

Some bacteria evade immune detection by spreading directly between host cells. This intercellular route facilitates bacterial dissemination within the host organism.

Keywords:

cell to cell spread francisella tularensis immunology infectious disease microbiology mouse salmonella typhimurium trogocytosis

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Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Published on: August 12, 2021

Area of Science:

Microbiology
Immunology
Cell Biology

Background:

Bacterial infections pose significant health challenges.
Immune evasion is a key factor in bacterial pathogenesis.
Understanding bacterial dissemination mechanisms is crucial for developing new therapies.

Purpose of the Study:

To investigate the role of direct host cell-to-cell contact in bacterial spread.
To elucidate the mechanisms by which bacteria utilize this route to evade immune surveillance.

Main Methods:

Utilized in vitro co-culture models of host cells and bacteria.
Employing live-cell imaging and fluorescence microscopy to track bacterial movement.
Immunofluorescence staining to assess immune cell presence and activity.

Main Results:

Observed direct transfer of bacteria between adjacent host cells.
Demonstrated that bacteria in direct cell-to-cell contact are shielded from immune cells.
Quantified the efficiency of spread via this intercellular route.

Conclusions:

Direct contact between host cells provides a novel pathway for bacterial dissemination.
This mechanism allows bacteria to bypass immune system detection and clearance.
Targeting intercellular bacterial spread could be a promising therapeutic strategy.