Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...

Seizures: Classification

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantification of patent foramen ovale shunt severity by transesophageal echocardiogram and transcranial doppler in routine clinical practice.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2025

Same author

Atrial Arrhythmias After PFO Device Closure: Common, Clinically Important, and Preventable?

Circulation·2024

Same author

Some Practical Points About Patent Foramen Ovale Conditions that May Not Be Covered in the Rest of the Book.

Cardiology clinics·2024

Same author

Patent Foramen Ovale and Acute Mountain Sickness.

Cardiology clinics·2024

Same author

Patent Foramen Ovale and Coronary Artery Spasm: A New Patent Foramen Ovale-associated Condition that May Explain the Mechanism of Vasospastic Angina.

Cardiology clinics·2024

Same author

The Current State of Science Surrounding Patent Foramen Ovale.

Cardiology clinics·2024

Same journal

Mechanical Thrombus Aspiration for a Young STEMI Patient With Plaque Erosion: Time for a Stent-Free Approach?

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

Same journal

First Report of Hybrid Brachial Artery Access Enabling Complex Coronary Intervention.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

Same journal

Retrograde Balloon Pulmonary Angioplasty for Otherwise Uncrossable Lesions in Chronic Thromboembolic Pulmonary Hypertension.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

Same journal

Same-Day Discharge After Transcatheter Aortic Valve Implantation: Who, When, and How?

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

Same journal

Comparative Outcomes of Transcatheter Versus Surgical Pulmonary Valve Replacement in Adults With Congenital Heart Disease.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

Same journal

Validation of the European Society of Cardiology Ischemic and Bleeding Risk Criteria for Risk Stratification After Endovascular Therapy in Japanese Patients With Lower Extremity Artery Disease.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 25, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Putting cryptogenic stroke into perspective.

Jonathan M Tobis¹

¹Professor of Medicine, Division of Cardiology, UCLA.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions

|February 27, 2016

Summary

This summary is machine-generated.

Older patients (>55) with cryptogenic stroke and patent foramen ovale (PFO) closure face higher cerebral ischemia recurrence. Most recurrent events in this group had identifiable causes, aligning with RESPECT trial findings.

More Related Videos

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

Related Experiment Videos

Last Updated: Mar 25, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

Area of Science:

Neurology
Cardiology
Vascular Medicine

Background:

Cryptogenic stroke patients with patent foramen ovale (PFO) closure show varying recurrence rates.
Age is a critical factor influencing the risk of recurrent cerebral ischemia after PFO closure.

Discussion:

In patients over 55 with cryptogenic stroke and PFO closure, a higher recurrence rate of cerebral ischemia was observed.
The majority of recurrent events in older individuals were attributed to identifiable secondary causes, not the PFO itself.

Key Insights:

Age significantly impacts the risk of recurrent cerebral ischemia post-PFO closure in cryptogenic stroke patients.
Identifying secondary causes is crucial for managing recurrent events in older patients undergoing PFO closure.

Outlook:

Further research should focus on risk stratification and tailored medical management for older cryptogenic stroke patients with PFO.
These findings support a nuanced approach to PFO closure, considering patient age and potential secondary causes of stroke.