Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

595
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
595
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

2.8K
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
2.8K
Introduction to Electrolytes01:33

Introduction to Electrolytes

17.8K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
17.8K
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

1.3K
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
1.3K
Phosphate Buffer01:22

Phosphate Buffer

6.0K
The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
6.0K
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

4.4K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potassium Homeostasis in Health and Disease: A Scientific Workshop Cosponsored by the National Kidney Foundation and the American Society of Hypertension.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2017
Same author

Potassium homeostasis in health and disease: A scientific workshop cosponsored by the National Kidney Foundation and the American Society of Hypertension.

Journal of the American Society of Hypertension : JASH·2017
Same author

Examining the Proportion of Dietary Phosphorus From Plants, Animals, and Food Additives Excreted in Urine.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2016
Same author

Passing the gavel.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2015
Same author

The National Kidney Foundation Council on Renal Nutrition addresses the Food and Drug Administration.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2014
Same author

Addressing the FDA.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation·2014

Related Experiment Video

Updated: Mar 25, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

9.8K

An Update on Phosphate Binders: A Dietitian's Perspective.

Lisa Gutekunst1

  • 1Davita, Inc., Denver, CO, Keryx Biopharmaceuticals, New York, New York.

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
|February 28, 2016
PubMed
Summary

Managing serum phosphorus (PO4) is crucial for chronic kidney disease (CKD) patients. This review covers common phosphate binders, their use in CKD, and novel management strategies.

More Related Videos

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.9K
A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
10:17

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

Published on: April 29, 2022

2.9K

Related Experiment Videos

Last Updated: Mar 25, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

9.8K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.9K
A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
10:17

A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors

Published on: April 29, 2022

2.9K

Area of Science:

  • Nephrology
  • Clinical Nutrition
  • Pharmacology

Background:

  • Serum phosphorus (PO4) control is a key management goal for patients with chronic kidney disease (CKD).
  • Phosphate binders were developed in the 1970s to treat hyperphosphatemia in dialysis patients.
  • Aluminum-based binders are rarely used now due to the availability of safer alternatives.

Purpose of the Study:

  • To provide a comprehensive review of common phosphate binder categories for renal dietitians.
  • To discuss the pharmacokinetics, side effects, dosing, and controversies surrounding phosphate binder use.
  • To review novel approaches and a new calculation for comparing binders in CKD patients on dialysis.

Main Methods:

  • Literature review of common phosphate binder categories.
  • Discussion of pharmacokinetics, side effects, dosing, and phosphate affinity.
  • Inclusion of novel serum PO4 management strategies and a comparative calculation.

Main Results:

  • Aluminum binders are seldom used today, with many safer options available.
  • The review details various binder categories, their properties, and clinical considerations.
  • Novel management strategies and a new binder comparison calculation are presented.

Conclusions:

  • Effective phosphate binder selection and management are essential for CKD patients.
  • Renal dietitians play a vital role in optimizing phosphate binder therapy.
  • Newer approaches offer improved strategies for managing hyperphosphatemia in CKD.