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Updated: Mar 25, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Unplanned pregnancy and risk of maternal depression: secondary data analysis from a prospective pregnancy cohort
Alexandre Faisal-Cury1, Paulo Rossi Menezes1, Julieta Quayle1
1a Department of Preventive Medicine , University of São Paulo , São Paulo , Brazil.
Purpose:
to evaluate the relationship between unplanned pregnancy (UP), a common problem in high and low income countries and maternal depression (MD).
Methods:
Secondary analysis of data from a prospective cohort study with pregnant women recruited from 10 primary care clinics of the public sector in São Paulo, Brazil. Participants were questioned about pregnancy intention at 20-30 weeks of gestation. The Self Report Questionnaire score >7 was used to evaluated the presence of depression during pregnancy and 11 months after childbirth. Four groups of MD were defined: never; antenatal only; postnatal only; persistent (both antenatal/postnatal). Multinomial logistic regression was used to assess the relationship between UP and MD, controlling for confounding.
Results:
Data were analysed for 701 at the postpartum period. Five hundred and sixty-two (67.8%) women did not plan the pregnancy. Women with UP had 2.5 more risk of being depressed during both assessments (during pregnancy and postpartum) when compared to women with a planned pregnancy (RR: 2.5; 95% CI: 1.47:4.30). In the adjusted models, women with UP were significantly more likely to have persistent depression (RR: 2.3; 95% CI: 1.2:4.3).
Conclusion:
UP is an independent risk factor for persistent depression, but not for postpartum depression.
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