Related Experiment Video
Updated: Mar 25, 2026
Author Spotlight: Advancing Labor Management Through Electromyometrial Imaging for Understanding Uterine Contractions
Published on: May 26, 2023
A mathematical model to simulate the cardiotocogram during labor. Part B: Parameter estimation and simulation of
Germaine J L M Jongen1, M Beatrijs van der Hout-van der Jagt1, Frans N van de Vosse2
1Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Department of Gynecology and Obstetrics, Máxima Medical Center, Veldhoven, The Netherlands.
During labor and delivery the cardiotocogram (CTG), the combined registration of fetal heart rate (FHR) and uterine contractions, is used to monitor fetal well-being. In part A of our study we introduced a new mathematical computer model for CTG simulation in order to gain insight into the complex relation between these signals. By reducing model complexity and by using physically more realistic descriptions, this model was improved with respect to our previous model. Aim of part B of this study is to gain insight into the cascade of events from uterine contractions causing combined uterine flow reduction and umbilical cord compression, resulting in blood and oxygen pressure variations, which lead to changes in FHR via the baro- and chemoreflex. In addition, we extensively describe and discuss the estimation of model parameter values. Simulation results are in good agreement with sheep data and show the ability of the model to describe variable decelerations. Despite reduced model complexity, parameter estimation still remains difficult due to limited clinical data.
During labor and delivery the cardiotocogram (CTG), the combined registration of fetal heart rate (FHR) and uterine contractions, is used to monitor fetal well-being. In part A of our study we introduced a new mathematical computer model for CTG simulation in order to gain insight into the complex relation between these signals. By reducing model complexity and by using physically more realistic descriptions, this model was improved with respect to our previous model. Aim of part B of this study is to gain insight into the cascade of events from uterine contractions causing combined uterine flow reduction and umbilical cord compression, resulting in blood and oxygen pressure variations, which lead to changes in FHR via the baro- and chemoreflex. In addition, we extensively describe and discuss the estimation of model parameter values. Simulation results are in good agreement with sheep data and show the ability of the model to describe variable decelerations. Despite reduced model complexity, parameter estimation still remains difficult due to limited clinical data.
More Related Videos
Related Concept Videos
01:25Correlation between ECG and Cardiac Cycle
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
01:19Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
01:11Cardiac Output and Stroke Volume
In an average resting adult male, the typical cardiac...
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...